CBS 7435

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DetailsTypeFeatureGene nameGene descriptionS.cerevisiae Gene NameS.cerevisiae Systematic NameGS115 HomologUniprotidProtein Length
genePP7435_Chr1-0001PP7435_Chr1-0001Hypothetical protein conservedNANAPAS_chr1-3_0003F2QL95_KOMPC494
genePP7435_Chr1-0002XUT5Putative xylose transporter, similar to S. stipitis XUT5NANAPAS_chr1-3_0004F2QL96_KOMPC499
genePP7435_Chr1-0003PP7435_Chr1-0003Protein with low similarity to phytanoyl- dioxygenasesNANAPAS_chr1-3_0005F2QL97_KOMPC376
genePP7435_Chr1-0004PP7435_Chr1-0004Hypothetical protein not conservedNANAPAS_chr1-3_0008F2QL98_KOMPC138
genePP7435_Chr1-0005PP7435_Chr1-0005Hypothetical protein not conservedNANA F2QL99_KOMPC80
genePP7435_Chr1-0006PP7435_Chr1-0006Hypothetical protein conserved (domain: GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain and fungal_TF_MHR (fungal transcription factor regulatory middle homology region)NANAPAS_chr1-3_0010F2QLA0_KOMPC606
genePP7435_Chr1-0007GTH1P. pastoris high affinity glucose transporter, similar to K. lactis HGT1 (P. pastoris)NANAPAS_chr1-3_0011F2QLA1_KOMPC542
genePP7435_Chr1-1598PP7435_Chr1-1598Hypothetical protein not conservedNANA A0A1G4KNW9_KOMPC63
genePP7435_Chr1-0008PP7435_Chr1-0008Protein with low similarity to isochorismatase family hydrolaseNANAPAS_chr1-3_0013F2QLA2_KOMPC199
genePP7435_Chr1-0009FMO1-1Flavin-containing monooxygenase, localized in S. cerevisiae to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteinsFMO1YHR176WPAS_chr1-3_0014F2QLA3_KOMPC459
genePP7435_Chr1-0010PP7435_Chr1-0010Protein with low similarity to putative transcriptional regulatory proteinsNANAPAS_chr1-3_0015F2QLA4_KOMPC660
genePP7435_Chr1-0011PP7435_Chr1-0011Protein with low similarity to short-chain dehydrogenase dehydrogenasesNANAPAS_chr1-3_0016F2QLA5_KOMPC256
genePP7435_Chr1-0012YCT1High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; in S. cerevisiae the green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum and YCT1 is not an essential geneYCT1YLL055WPAS_chr1-3_0017F2QLA6_KOMPC541
genePP7435_Chr1-0013PP7435_Chr1-0013Hypothetical protein not well conserved (domain: Zn2Cys6 binuclear cluster DNA-binding domain)NANAPAS_chr1-3_0018F2QLA7_KOMPC735
genePP7435_Chr1-1609PP7435_Chr1-1609Hypothetical protein not conservedNANA A0A1G4KP07_KOMPC60
genePP7435_Chr1-0014PP7435_Chr1-0014Hypothetical protein not conservedNANAPAS_chr1-3_0020A0A1G4KP24_KOMPC388
genePP7435_Chr1-0016KAP104Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosisKAP104YBR017CPAS_chr1-3_0022F2QLA9_KOMPC925
genePP7435_Chr1-0017DAL1Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression in S. cerevisiae sensitive to nitrogen catabolite repressionDAL1YIR027CPAS_chr1-3_0023F2QLB0_KOMPC662
genePP7435_Chr1-0018UGA2Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized in S. cerevisiae to the cytoplasmUGA2YBR006WPAS_chr1-3_0024F2QLB1_KOMPC496
genePP7435_Chr1-0019RAD57Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55pRAD57YDR004WPAS_chr1-3_0025A0A1G4KNY4_KOMPC515
genePP7435_Chr1-0020MAF1Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; in S. cerevisiae localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p, localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditionsMAF1YDR005CPAS_chr1-3_0026F2QLB3_KOMPC330
genePP7435_Chr1-0021PHM7Protein of unknown function; expression is regulated by phosphate levels; in S. cerevisiae the green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole and protein abundance increases in response to DNA replication stressPHM7YOL084WPAS_chr1-3_0027F2QLB4_KOMPC899
genePP7435_Chr1-0022IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential in S. cerevisiae for viability, active-site residues show identity to those from E. coli PpaseIPP1YBR011CPAS_chr1-3_0028F2QLB5_KOMPC287
genePP7435_Chr1-0023TRP1Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)TRP1YDR007WPAS_chr1-3_0029F2QLB6_KOMPC238
genePP7435_Chr1-0024RFC4Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; in S. cerevisiae relocalizes to the cytosol in response to hypoxiaRFC4YOL094CPAS_chr1-3_0030F2QLB7_KOMPC325
genePP7435_Chr1-0025VPS52Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitinVPS52YDR484WPAS_chr1-3_0031F2QLB8_KOMPC586
genePP7435_Chr1-0026TAX4EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; Pichia pastoris does not have the paralog IRS4TAX4YJL083WPAS_chr1-3_0032F2QLB9_KOMPC574
genePP7435_Chr1-0027HMT1Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.HMT1YBR034CPAS_chr1-3_0033F2QLC0_KOMPC344
genePP7435_Chr1-0028RPL4ARibosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; Pichia pastoris does not have the paralog RPL4BRPL4AYBR031WPAS_chr1-3_0034F2QLR1_KOMPC340
genePP7435_Chr1-0029GLC3Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; in S. cerevisiae relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.GLC3YEL011W F2QLR2_KOMPC701
genePP7435_Chr1-0030GSM1Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression in S. cerevisiae and sequence analysisGSM1YJL103CPAS_chr1-3_0036F2QLR3_KOMPC532
genePP7435_Chr1-0031SET3Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; Pichia pastoris does not have the paralog SET4SET3YKR029CPAS_chr1-3_0037F2QLR4_KOMPC943
genePP7435_Chr1-0032PAM16Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domainPAM16YJL104WPAS_chr1-3_0038F2QLR5_KOMPC129
genePP7435_Chr1-1620PP7435_Chr1-1620Hypothetical protein not conservedNANA A0A1G4KP18_KOMPC72
genePP7435_Chr1-0033PP7435_Chr1-0033Hypothetical protein conserved (domain: Zinc finger and cleavage and polyadenylation specificity factor, YTH1)NANAPAS_chr1-3_0039F2QLR6_KOMPC357
genePP7435_Chr1-0034PP7435_Chr1-0034Protein with similarity to YKR023W (Putative protein of unknown function; in S. cerevisiae the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies)YKR023WYKR023WPAS_chr1-3_0040F2QLR7_KOMPC530
genePP7435_Chr1-0035IME2Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression in S. cerevisiae is positively regulated by Ime1pIME2YJL106WPAS_chr1-3_0041F2QLR8_KOMPC712
genePP7435_Chr1-0037PRM10-2Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced in S. cerevisiae by treatment with 8-methoxypsoralen and UVA irradiationPRM10YJL108CPAS_chr1-3_0043F2QLR9_KOMPC959
genePP7435_Chr1-0038PRM10-1Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced in S. cerevisiae by treatment with 8-methoxypsoralen and UVA irradiationPRM10YJL108CPAS_chr1-3_0044F2QLS0_KOMPC1016
genePP7435_Chr1-0039SCP160Essential RNA-binding G protein effector of mating response pathway in S. cerevisiae, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilinsSCP160YJL080CPAS_chr1-3_0045F2QLS1_KOMPC1009
genePP7435_Chr1-0040PP7435_Chr1-0040Protein with similarity to YFR016C (Putative protein of unknown function; in S. cerevisiae the green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud, interacts with Spa2p and YFL016C is not an essential gene)YFR016CYFR016CPAS_chr1-3_0046F2QLS2_KOMPC556
genePP7435_Chr1-0041PP7435_Chr1-0041Protein with low similarity to DnaJ subfamily C proteinsNANAPAS_chr1-3_0047F2QLS3_KOMPC396
genePP7435_Chr1-0042CDC34Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance in S. cerevisiae increases in response to DNA replication stressCDC34YDR054CPAS_chr1-3_0048F2QLS4_KOMPC236
genePP7435_Chr1-0043PP7435_Chr1-0043Hypothetical protein not conservedNANAPAS_chr1-3_0049A0A1G4KP19_KOMPC168
genePP7435_Chr1-0044DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stressDBF4YDR052CPAS_chr1-3_0050F2QLS6_KOMPC499
genePP7435_Chr1-0045PP7435_Chr1-0045Protein with low similarity to C6 transcription factorsNANAPAS_chr1-3_0051F2QLS7_KOMPC175
genePP7435_Chr1-0046BIO2Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; the S. cerevisiae protein complements E. coli bioB mutantBIO2YGR286CPAS_chr1-3_0052F2QLS8_KOMPC397
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